An ancient pestilence called The Scourge has been set free in a small town after being entombed in a church's masonry for a century and a half. As bodies rapidly pile up, nothing stands between the spawning Scourge and the rest of the town except our young heroes Scott and Jessie who rediscover their love for each other in the process.

After losing contact with its researchers on a remote island, a military corporation hires a group of scientists and soldiers to find out what went wrong. When they arrive, the team quickly discovers that experiments performed on the island have unleashed a powerful and deadly entity that will stop at nothing to destroy them all.